Intris: A Viewer for Splice Variants and their Expression Profiles --- Summarization into Variant Types

تأثیر آدنوزین ´5تری فسفات در القای آپوپتوز و مهار بیان ژن Survivin و واریانت پیرایشی ضد آپوپتوزی SUR-3B آن در سلول های K562

Introduction: Leukemia is a heterogeneous malignant disease in which progression at the level of CD34+ cells has a major impact in drug resistance and relapse. The multi-drug resistance gene product, P-glycoprotein is an inhibitor of apoptosis proteins (IAPs), such as Survivin that are expressed simultaneously with several putative drug resistance parameters in CD34+ leukemia cells. In fact, IA...

مطالعه‌ی بیان ژنSurvivin و واریانت‌های پیرایشی ΔEx3٬ 2b و 3b آن به عنوان تومور مارکرهای تشخیصی در سرطان پستان

Introduction: Survivin is a new member of the Inhibitor Apotosis Protein family (IAP) which plays an important role in the regulation of both cell cycle and apoptosis. Its distinct expression in tumor cells as compared to normal adult cells introduces Survivin as the fourth transcriptom demonstrated in tumors. Breast cancer is the most common malignancy among women and scientist`s efforts to cl...

Expression profile of ZFX isoform3/variant 5 in gastric cancer tissues and its association with tumor size

Objective(s):Previous studies demonstrate that changes in pre-mRNA splicing play a significant role in human disease development. Furthermore, many cancer-associated genes are regulated by alternative splicing. There are mounting evidences that splice variants which express predominantly in tumors, have clear diagnostic value and may provide potential drug targets. Located on the X chromosome, ...

Comparison of Expression of Growth Hormone-Releasing Hormone and Its Receptor Splice Variant 1 in Different Stages of Endometriosis

بررسی بیان ژن Survivin و واریانت‌های پیرایشی 2B و ΔEx3 آن به عنوان مارکرهای مولکولی تشخیصی جدید در تومورهای تیروئیدی

Evaluating the Expression of Survivin and Its Splice Variants 2B and ΔEx3 as New Diagnostic Molecular Markers in Thyroid Cancer Vandghanooni S1, Hosseinpour Feizi MA1, Babaei E1,2, Montazeri V3, Halimi M3 1 Dept of Biology, School of Nature Sciences, Tabriz University, Tabriz, Iran 2 Dept of Genetics, Faculty of Basic Sciences, Tarbiat Modarres University, Tehran, Iran 3 Imam Khomeini Hospital,...